Given the high percentage of diabetic patients who are not achieving ADA/AACE glycemic goals, it is imperative that appropriate diabetes treatment regimens are initiated and intensified in a timely manner. Even with the addition of basal insulin, only about 40% of patients achieve an A1C target of <7%, and in some patients hyperglycemia persists despite reaching an A1C of <7%. With the continued loss of beta cells and subsequent decline of insulin secretory capacity, postprandial hyperglycemia becomes the dominant glycemic control target. In this activity, learn more about the clinical profiles of the different GLP-1 receptor agonists (GLP-1 RAs), the differences in guideline recommendations regarding use of GLP-1 RAs and their role in combination with basal insulin for reducing postprandial glucose. Dr. Fonseca will take you through frequently asked questions regarding use of GLP-1 RAs in clinical practice and their impact on postprandial hyperglycemia.

Learning Objectives

  • Compare and contrast the clinical profiles of the different GLP-1 receptor agonists
  • Outline the differences in guideline recommendations regarding use of GLP-1 receptor agonists in patients with type 2 diabetes
  • Discuss the role of GLP-1 receptor agonists in combination with basal insulin for reducing postprandial glucose

Faculty Disclosures

Vivian A. Fonseca, MD, FRCP

Speaker's Bureaus for AstraZeneca; Novo Nordisk Inc.; Sanofi US. Advisory Boards for Amgen; AstraZeneca; Janssen Pharmaceuticals, Inc.; Lilly; Novo Nordisk Inc.; Sanofi US; Takeda Pharmaceuticals U.S.A., Inc. Contracted Research for Asahi Kasei Pharma America; Bayer; GI Dynamics, Inc.; and Gilead Sciences Medical Affairs. Ownership Interest (e.g. stocks, stock option, etc.) in MicroBiome Therapeutics.


Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.

CME Information


AMA PRA Category 1 Credits

Accreditation Statement

pmiCME is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation Statement

pmiCME designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.



Accreditation Statement

pmiCME is approved as a provider of nurse practitioner continuing education by the American Association of Nurse Practitioners. AANP Provider number 040308. This activity was planned in accordance with AANP Accreditation Standards and Policies.

Designation Statement

This program has been approved for 0.50 contact hour of continuing education, which includes 0 hours of pharmacology.

Instructions for Obtaining Credit

Once you have completed the activity, please click the "next" button to advance to the post-activity assessment. To complete this activity and claim credit, you must answer 2 out of the 3 questions correctly. If you are not successful after your first attempt, you will be given an opportunity to reflect upon the answer rationales and have the opportunity to review the educational content before proceeding. Once you have selected your answers, click the "submit" button to complete the evaluation questions and proceed to the claim credit screen.

Commercial Supporter

Sanofi US

Education Partner

Horizon CME

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GLP-1 Receptor Agonists – An Emerging Standard for Therapy Intensification in Type 2 Diabetes